{"product_id":"msh6-monoclonal-antibody-bt-mca2506","title":"MSH6 Monoclonal Antibody - BT-MCA2506","description":"\u003cp\u003eMSH6 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2506-50, BT-MCA2506-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MSH6\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1D10G1\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MSH6\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human MSH6 (AA: 217-395) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 152.8kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P52701\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: GTBP, HSAP, p160, GTMBP, HNPCC5\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2956\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238377611443,"sku":"BT-MCA2506-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238377644211,"sku":"BT-MCA2506-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_8093b13b-19dc-4702-a46e-995c38d118a3.png?v=1769379491","url":"https:\/\/afsbio.com\/products\/msh6-monoclonal-antibody-bt-mca2506","provider":"AFSBio Inc.","version":"1.0","type":"link"}