{"product_id":"msh6-monoclonal-antibody-bt-mca2810","title":"MSH6 Monoclonal Antibody - BT-MCA2810","description":"\u003cp\u003eMSH6 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2810-50, BT-MCA2810-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MSH6\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 3E1\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2a\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MSH6\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human MSH6 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 160kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P52701\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: GTBP, HSAP, HNPCC5\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2956\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238580543667,"sku":"BT-MCA2810-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238580576435,"sku":"BT-MCA2810-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_fcec504a-c51b-4fe5-9173-1aa2a42a1892.png?v=1769382781","url":"https:\/\/afsbio.com\/products\/msh6-monoclonal-antibody-bt-mca2810","provider":"AFSBio Inc.","version":"1.0","type":"link"}