{"product_id":"msh6-monoclonal-antibody-bt-mca4287","title":"MSH6 Monoclonal Antibody - BT-MCA4287","description":"\u003cp\u003eMSH6 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4287-50, BT-MCA4287-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MSH6\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 3A10H7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MSH6\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of MSH6 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P52701\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: GTBP, HSAP, HNPCC5\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2956\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238369157299,"sku":"BT-MCA4287-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238369190067,"sku":"BT-MCA4287-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f5250ee7-2e8b-4f65-8e44-6148b7a05d34.png?v=1769379291","url":"https:\/\/afsbio.com\/products\/msh6-monoclonal-antibody-bt-mca4287","provider":"AFSBio Inc.","version":"1.0","type":"link"}