{"product_id":"msr1-polyclonal-antibody-e-ab-66237","title":"MSR1 Polyclonal Antibody - E-AB-66237","description":"\u003cp\u003eMSR1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-66237-60, E-AB-66237-120, E-AB-66237-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MSR1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MSR1; CD204; SCARA1; SR-A; SR-AI; SR-AII; SR-AIII; SRA; phSR1; phSR2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cardiovascular,Metabolism,Immunology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P21757\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human MSR1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 39kDa\/42kDa\/49kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60-90kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146411212979,"sku":"E-AB-66237-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146411245747,"sku":"E-AB-66237-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146411278515,"sku":"E-AB-66237-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_4d6bc7eb-fe93-4500-963a-4806c415d7ed.png?v=1710295098","url":"https:\/\/afsbio.com\/products\/msr1-polyclonal-antibody-e-ab-66237","provider":"AFSBio Inc.","version":"1.0","type":"link"}