{"product_id":"mst-3-rabbit-polyclonal-antibody-es2861","title":"MST-3 Rabbit Polyclonal Antibody - ES2861","description":"\u003cp\u003eMST-3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2861-50, ES2861-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a serine\/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases, the N-terminal fragment (MST3\/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: STK24, MST3, STK3, Serine\/threonine-protein kinase 24, Mammalian STE20-like protein kinase 3, MST-3, STE20-like kinase MST3\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human STK24. AA range:319-368\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: MST3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MST-3 Polyclonal Antibody detects endogenous levels of MST-3 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Isoform A is ubiquitous, Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 50kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein\u003cbr\u003e\nCofactor: Manganese. Only isoform A requires manganese\u003cbr\u003e\nFunction: Protein kinase that act on both serine and threonine residues\u003cbr\u003e\nPTM: Autophosphorylated. Isoform B is activated by phosphorylation by PKA\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. STE Ser\/Thr protein kinase family. STE20 subfamily\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nTissue Specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm Nucleus Membrane The truncated form (MST3\/N) translocates to the nucleus Colocalizes with STK38L in the membrane\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: STK24\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Serine\/threonine-protein kinase 24\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 223255\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q99KH8\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 361092\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: B0LT89\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314234708147,"sku":"ES2861-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314234740915,"sku":"ES2861-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/mst-3-rabbit-polyclonal-antibody-es2861","provider":"AFSBio Inc.","version":"1.0","type":"link"}