{"product_id":"mthfd2-monoclonal-antibody-mb66881","title":"MTHFD2 Monoclonal Antibody-MB66881","description":"\u003cp\u003eMTHFD2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66881-50, MB66881-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P13995\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/1000 - 1\/2000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: MTHFD2 is a bifunctional methylenetetrahydrofolate dehydrogenase\/cyclohydrolase involved in mitochondrial folate metabolism . MTHFD2 expression is developmentally regulated, as it is expressed in embryos but not in most adult tissues. Recent research studies have shown that MTHFD2 is consistently overexpressed in many cancer types and correlated with poor survival in breast cancer . Overexpression of MTHFD2 promotes cell proliferation while its depletion induces cell death in human cancer cells .\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of MTHFD2 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of MTHFD2 expression in Hela (A), 293 (B), MOLT4 (C), mouse heart (D) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 40 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: NMDMC; Bifunctional methylenetetrahydrofolate dehydrogenase\/cyclohydrolase, mitochondrial\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MTHFD2. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906391085235,"sku":"MB66881-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906391118003,"sku":"MB66881-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_90ef5d74-fe71-49f5-96af-37b91fb220f3.jpg?v=1702918978","url":"https:\/\/afsbio.com\/products\/mthfd2-monoclonal-antibody-mb66881","provider":"AFSBio Inc.","version":"1.0","type":"link"}