{"product_id":"mtnr1a-polyclonal-antibody-bs60605","title":"MTNR1A Polyclonal Antibody-BS60605","description":"\u003cp\u003eMTNR1A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS60605-50, BS60605-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor; MTNR1A\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P48039\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Melatonin (Mel), a hormone secreted by the pineal gland, is expressed at night in response to the circadian clock. Melatonin is thought to be involved in regulating reproductive physiological development and the progression of sexual maturation, and it is also thought to play a role in tumorigenesis. The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the super-family of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. Signaling through the melatonin receptors inhibits adenylate cyclase and stimulates phospholipase Cb upon activation of pertussis toxin (PTX)-sensitive G proteins. MEL-1A-R may be involved in pacing the biological clock. However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MTNR1A polyclonal antibody detects endogenous levels of MTNR1A protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 39 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of MTNR1A polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: A549 whole cell lysate\u003cbr\u003e\nLane 2: sp2\/0 whole cell lysate \u003cbr\u003e\nLane 3: PC12 whole cell lysate\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: A synthetic peptide corresponding to residues in Human MTNR1A\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42913694056627,"sku":"BS60605-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42913694089395,"sku":"BS60605-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_1533c4c1-1cc1-4466-ba7b-942163c198e5.jpg?v=1703266741","url":"https:\/\/afsbio.com\/products\/mtnr1a-polyclonal-antibody-bs60605","provider":"AFSBio Inc.","version":"1.0","type":"link"}