{"product_id":"musk-monoclonal-antibody-bt-mca4420","title":"MUSK Monoclonal Antibody - BT-MCA4420","description":"\u003cp\u003eMUSK Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4420-50, BT-MCA4420-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction, Tags and, cell markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MUSK\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, ICC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 10A4\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MUSK\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 97kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: O15146\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: muscle, skeletal, receptor tyrosine kinase\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4593\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238638248115,"sku":"BT-MCA4420-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238638280883,"sku":"BT-MCA4420-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1c8c9895-89af-4327-a346-37506bd96b5f.png?v=1769383305","url":"https:\/\/afsbio.com\/products\/musk-monoclonal-antibody-bt-mca4420","provider":"AFSBio Inc.","version":"1.0","type":"link"}