{"product_id":"myh-rabbit-polyclonal-antibody-es2874","title":"MYH Rabbit Polyclonal Antibody - ES2874","description":"\u003cp\u003eMYH Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2874-50, ES2874-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MUTYH, MYH, A\/G-specific adenine DNA glycosylase, MutY homolog, hMYH\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human MUTYH. AA range:151-200\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: MYH\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MYH Polyclonal Antibody detects endogenous levels of MYH protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Kidney,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 60kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Base excision repair\u003c\/p\u003e\n\n\u003cp\u003eFunction: Cofactor: Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand\u003cbr\u003e\nDisease: Defects in MUTYH are a cause of autosomal recessive colorectal adenomatous polyposis [MIM: 608456]\u003cbr\u003e\nDisease: Defects in MUTYH are a cause of gastric cancer [MIM: 137215]\u003cbr\u003e\nFunction: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities\u003cbr\u003e\nSimilarity: Belongs to the nth\/mutY family\u003cbr\u003e\nSimilarity: Contains 1 nudix hydrolase domain\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Nucleus Mitochondrion\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: MUTYH\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: A\/G-specific adenine DNA glycosylase\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 70603\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q99P21\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 170841\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q8R5G2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314235035827,"sku":"ES2874-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314235068595,"sku":"ES2874-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/myh-rabbit-polyclonal-antibody-es2874","provider":"AFSBio Inc.","version":"1.0","type":"link"}