{"product_id":"nalp12-monoclonal-antibody-mb67033","title":"NALP12 Monoclonal Antibody-MB67033","description":"\u003cp\u003eNALP12 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB67033-50, MB67033-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: E9Q5R7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Plays an essential role as an potent mitigator of inflammation.Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways .Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway .In turn, promotes bacterial tolerance.Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (By similarity).Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue .\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of NALP12 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of NALP12 expression in mouse brain (A) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 119 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: NALP12; PYPAF7; RNO; NACHT, LRR and PYD domains-containing protein 12; Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human NALP12. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906405044403,"sku":"MB67033-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906405077171,"sku":"MB67033-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b115dd8c-0d9d-42e1-aeb0-fa265600fd70.jpg?v=1702919091","url":"https:\/\/afsbio.com\/products\/nalp12-monoclonal-antibody-mb67033","provider":"AFSBio Inc.","version":"1.0","type":"link"}