{"product_id":"ncx1-polyclonal-antibody-bt-ap05816","title":"NCX1 Polyclonal Antibody - BT-AP05816","description":"\u003cp\u003eNCX1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05816-20, BT-AP05816-50, BT-AP05816-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SLC8A1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: NCX1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 108547\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P32418; Mouse: P70414; Rat: Q01728\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SLC8A1; CNC; NCX1; Sodium\/calcium exchanger 1; Na(+)\/Ca(2+)-exchange protein 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6546; Mouse: 20541; Rat: 29715\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239726244019,"sku":"BT-AP05816-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239726276787,"sku":"BT-AP05816-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239726309555,"sku":"BT-AP05816-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1de96d33-5a85-4268-ae11-4b6eadd73fc8.png?v=1769398525","url":"https:\/\/afsbio.com\/products\/ncx1-polyclonal-antibody-bt-ap05816","provider":"AFSBio Inc.","version":"1.0","type":"link"}