{"product_id":"nd1-rabbit-pab-es2904","title":"ND1 rabbit pAb - ES2904","description":"\u003cp\u003eND1 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2904-50, ES2904-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:NADH + ubiquinone = NAD (+) + ubiquinol., disease:Defects in MT-ND1 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes., disease:Defects in MT-ND1 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS) [MIM:540000]. MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness., disease:Defects in MT-ND1 may be associated with mitochondrial susceptibility to Alzheimer disease (AD) [MIM:502500]., disease:Defects in MT-ND1 may be associated with non-insulin-dependent diabetes mellitus (NIDDM)., function:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., similarity:Belongs to the complex I subunit 1 family.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: MT-ND1; MTND1; NADH1; ND1; NADH-ubiquinone oxidoreductase chain 1; NADH dehydrogenase subunit 1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human MT-ND1. AA range:176-225\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 36kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 4535\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P03886\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Mitochondrion inner membrane; Multi-pass membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202105663667,"sku":"ES2904-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202105696435,"sku":"ES2904-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_20335244-bdde-434f-a15b-ac3925afd409.png?v=1767121994","url":"https:\/\/afsbio.com\/products\/nd1-rabbit-pab-es2904","provider":"AFSBio Inc.","version":"1.0","type":"link"}