{"product_id":"ndr2-rabbit-pab-es5289","title":"NDR2 rabbit pAb - ES5289","description":"\u003cp\u003eNDR2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES5289-50, ES5289-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1\/MOBKL1A and MOB2\/HCCA2 to the N-terminal of STK38L., function:Involved in the regulation of structural processes in differentiating and mature neuronal cells., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 protein kinase domain., subcellular location:Associated with the actin cytoskeleton., subunit:Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2., tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: STK38L; KIAA0965; NDR2; Serine\/threonine-protein kinase 38-like; NDR2 protein kinase; Nuclear Dbf2-related kinase 2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000.IHC-p:1:50-300 ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from NDR2 . at AA range: 380-460\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 54kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 23012\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9Y2H1\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Associated with the actin cytoskeleton. Co-localizes with STK24\/MST3 in the membrane.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202239815859,"sku":"ES5289-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202239848627,"sku":"ES5289-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_6fd62183-8b9e-43d8-8092-2636efa3c54c.png?v=1767124875","url":"https:\/\/afsbio.com\/products\/ndr2-rabbit-pab-es5289","provider":"AFSBio Inc.","version":"1.0","type":"link"}