{"product_id":"nedd4l-rabbit-polyclonal-antibody-ra33525","title":"NEDD4L Rabbit Polyclonal Antibody - RA33525","description":"\u003cp\u003eNEDD4L Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA33525-50, RA33525-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.08% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: E3 ubiquitin-protein ligase NEDD4-like (EC 6.3.2.-) (NEDD4.2) (Nedd4-2)\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 23327\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 110-120\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q96PU5\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122460450995,"sku":"RA33525-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122460483763,"sku":"RA33525-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f9d0bafc-6517-4aee-9f4a-34d98538e799.png?v=1773342507","url":"https:\/\/afsbio.com\/products\/nedd4l-rabbit-polyclonal-antibody-ra33525","provider":"AFSBio Inc.","version":"1.0","type":"link"}