{"product_id":"nedd8-monoclonal-antibody-bt-mca2330","title":"NEDD8 Monoclonal Antibody - BT-MCA2330","description":"\u003cp\u003eNEDD8 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2330-50, BT-MCA2330-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NEDD8\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5B8\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: NEDD8\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human NEDD8 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 9kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q15843\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: NEDD-8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4738\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238583853235,"sku":"BT-MCA2330-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238583886003,"sku":"BT-MCA2330-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_794eacae-36a1-4c4f-ad57-b652569476a2.png?v=1769382808","url":"https:\/\/afsbio.com\/products\/nedd8-monoclonal-antibody-bt-mca2330","provider":"AFSBio Inc.","version":"1.0","type":"link"}