{"product_id":"nedd8-polyclonal-antibody-e-ab-60222","title":"NEDD8 Polyclonal Antibody - E-AB-60222","description":"\u003cp\u003eNEDD8 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60222-60, E-AB-60222-120, E-AB-60222-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: NEDD8\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: NEDD8; NEDD-8\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q15843\u003c\/p\u003e\n\n\u003cp\u003eBackground: Nedd8 is an 81 amino acid Ub-like protein. It is conjugated to protein substrates in much the same way as Ub, using the E1, E2, E3 cascade. The specific E1 used is a heterodimer of APPBP1\/UBA3. Two E2s have been discovered to follow called Ubc12 and Ube2F. Neddylation causes conformational change of the Cullin protein in the E3 called cullin-RING ligases (CRLs), which enhances the E3 Ub ligase activity of CRLs.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human NEDD8\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 9kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 12kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146044309683,"sku":"E-AB-60222-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146044342451,"sku":"E-AB-60222-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146044375219,"sku":"E-AB-60222-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c8772294-14bc-4311-ae99-179a4431e294.png?v=1710290495","url":"https:\/\/afsbio.com\/products\/nedd8-polyclonal-antibody-e-ab-60222","provider":"AFSBio Inc.","version":"1.0","type":"link"}