{"product_id":"neddylin-polyclonal-antibody-bt-ap05872","title":"Neddylin Polyclonal Antibody - BT-AP05872","description":"\u003cp\u003eNeddylin Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05872-20, BT-AP05872-50, BT-AP05872-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: NEDD8 is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p53 pathway (Pathway Interaction Database). Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is UBA52.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NEDD8\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Neddylin Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 9072\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q15843; Mouse: P29595; Rat: Q71UE8\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: NEDD8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4738; Mouse: 18002; Rat: 25490\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239729324211,"sku":"BT-AP05872-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239729356979,"sku":"BT-AP05872-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239729389747,"sku":"BT-AP05872-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_8327cbc3-ab7c-41b0-8760-a3ea2bdc9e20.png?v=1769398564","url":"https:\/\/afsbio.com\/products\/neddylin-polyclonal-antibody-bt-ap05872","provider":"AFSBio Inc.","version":"1.0","type":"link"}