{"product_id":"neil3-rabbit-pab-es2917","title":"NEIL3 rabbit pAb - ES2917","description":"\u003cp\u003eNEIL3 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2917-50, ES2917-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg\/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: NEIL3; Endonuclease 8-like 3; DNA glycosylase FPG2; DNA glycosylase\/AP lyase Neil3; Endonuclease VIII-like 3; Nei-like protein 3\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human NEIL3. AA range:491-540\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 35kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 55247\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q8TAT5\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Chromosome. Recruited to replication stress sites via interaction with ubiquitinated CMG helicase.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202106450099,"sku":"ES2917-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202106482867,"sku":"ES2917-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_ee83c064-e57d-40b4-8a16-06aa70f033ef.png?v=1767122011","url":"https:\/\/afsbio.com\/products\/neil3-rabbit-pab-es2917","provider":"AFSBio Inc.","version":"1.0","type":"link"}