{"product_id":"nephrocystin-5-r467-polyclonal-antibody-bs3319","title":"Nephrocystin-5 (R467) Polyclonal Antibody-BS3319","description":"\u003cp\u003eNephrocystin-5 (R467) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3319-50, BS3319-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q15051\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e \n\n\u003cp\u003eBackground: The nephrocystin proteins comprise a family of five enzymes that commonly interact with p130Cas, proline-rich tyrosine kinases, calmodulin and tensin, indicating that these proteins may participate in a common signaling pathway. Localized to the outer segments and primary cilia of photoreceptor cells, nephrocystin-5 is complexed with RPGR (retinitis pigmentosa GTPase regulator) and interacts directly with calmodulin. Nephrocystin-5 is thought to participate with RPGR in a pathway of ciliary function in the kidey and retina. Mutations in the gene encoding nephrocystin-5 are the primary cause of Senior-Loken syndrome 5, a juvenile disorder characterized by defects in the waste filtering system of the kidney, as well as retinal degradation.\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Nephrocystin-5 (R467) polyclonal antibody detects endogenous levels of Nephrocystin-5 protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Nephrocystin-5 (R467) pAb at 1:1000 dilution\u003cbr\u003e\nLane 1: The Kidney tissue lysate of Mouse (5ug)\u003cbr\u003e\nLane 2: The Ovary tissue lysate of Rat (40ug)\u003cbr\u003e\nLane 3: HCT116 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Nephrocystin-5 (R467) pAb in paraffin-embedded human colon carcinoma tissue.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 69 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: IQ calmodulin-binding motif-containing protein 1; Nephrocystin-5; p53 and DNA damage-regulated IQ motif protein; PIQ; IQCB1; KIAA0036; NPHP5; OK\/SW-cl.85\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 432-486 of Human Nephrocystin-5.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953233793203,"sku":"BS3319-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953233825971,"sku":"BS3319-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_19103b6b-a11c-4cc3-a00b-a13f87059250.jpg?v=1705057349","url":"https:\/\/afsbio.com\/products\/nephrocystin-5-r467-polyclonal-antibody-bs3319","provider":"AFSBio Inc.","version":"1.0","type":"link"}