{"product_id":"neuregμlin-1-smdf-y4-polyclonal-antibody-bs1173","title":"Neuregμlin-1\/SMDF (Y4) Polyclonal Antibody - BS1173","description":"\u003cp\u003eNeuregμlin-1\/SMDF (Y4) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1173-50, BS1173-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The neuregμlins are a family of ErbB\/HER ligands encoded by four genes. Neuregμlin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregμlin-1 includes a range of isoforms with varying glycosylation, regμlation of expression and function. Neuregμlin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregμlin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregμlin-1 has been linked to schizophrenia and has diverse neural functions. Neuregμlin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregμlate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscμlar junctions.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Pro-neuregμlin-1, membrane-bound isoform, Pro-NRG1, Neuregμlin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregμlin, HRG, Neu differentiation factor, Sensory and motor neuron-derived factor, NRG1, GGF, HGL, HRGA, NDF, SMDF\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to the N-terminal of Human Neuregμlin-1\/SMDF.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SMDF\/Neuregμlin 1 (Y4) polyclonal antibody detects endogenous levels of SMDF\/Neuregμlin 1 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 44 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q15491\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45936732864691,"sku":"BS1173-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45936732897459,"sku":"BS1173-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image.jpg?v=1788296056","url":"https:\/\/afsbio.com\/products\/neureg%ce%bclin-1-smdf-y4-polyclonal-antibody-bs1173","provider":"AFSBio Inc.","version":"1.0","type":"link"}