{"product_id":"neuregulin-1-smdf-y4-polyclonal-antibody-bs1173","title":"Neuregulin-1\/SMDF (Y4) Polyclonal Antibody-BS1173","description":"\u003cp\u003eNeuregulin-1\/SMDF (Y4) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1173-50, BS1173-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q15491\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e \n\n\u003cp\u003eBackground: The neuregulins are a family of ErbB\/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SMDF\/Neuregulin 1 (Y4) polyclonal antibody detects endogenous levels of SMDF\/Neuregulin 1 protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Neuregulin-1 SMDF (Y4) pAb at 1:1000 dilution\u003cbr\u003e\nLane 1: PC12 whole cell lysate (40ug)\u003cbr\u003e\nLane 2: CT26 whole cell lysate (40ug)\u003cbr\u003e\nLane 3: PC3 whole cell lysate (40ug)\u003cbr\u003e\nLane 4: SK-OVCAR3 whole cell lysate (40ug)\u003cbr\u003e\nLane 5: MCF-7 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Neuregulin-1\/SMDF (Y4) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 44 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; Neuregulin-1; Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; Heregulin; HRG; Neu differentiation factor; Sensory and motor neuron-derived factor; NRG1; GGF; HGL; HRGA; NDF; SMDF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to the N-terminal of Human Neuregulin-1\/SMDF.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953207578803,"sku":"BS1173-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953207611571,"sku":"BS1173-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_d91bc6a5-0c7b-4498-b97f-a28c0bf81ae2.jpg?v=1705056773","url":"https:\/\/afsbio.com\/products\/neuregulin-1-smdf-y4-polyclonal-antibody-bs1173","provider":"AFSBio Inc.","version":"1.0","type":"link"}