{"product_id":"neurofibromin-polyclonal-antibody-bt-ap05927","title":"Neurofibromin Polyclonal Antibody - BT-AP05927","description":"\u003cp\u003eNeurofibromin Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05927-20, BT-AP05927-50, BT-AP05927-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: NF1 product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA\u0026gt;UGA-\u0026gt;Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NF1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Neurofibromin Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 319372\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P21359; Mouse: Q04690; Rat: P97526\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: NF1; Neurofibromin; Neurofibromatosis-related protein NF-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4763; Mouse: 18015; Rat: 24592\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239736041651,"sku":"BT-AP05927-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239736074419,"sku":"BT-AP05927-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239736107187,"sku":"BT-AP05927-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_6cb4b305-b5c3-4b5a-8c31-2cadcc57b262.png?v=1769398633","url":"https:\/\/afsbio.com\/products\/neurofibromin-polyclonal-antibody-bt-ap05927","provider":"AFSBio Inc.","version":"1.0","type":"link"}