{"product_id":"nf-κb-p105-phospho-ser933-rabbit-polyclonal-antibody-bt-ap00435","title":"NF-κB p105 (Phospho-Ser933) Rabbit Polyclonal Antibody - BT-AP00435","description":"\u003cp\u003eNF-κB p105 (Phospho-Ser933) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP00435-20, BT-AP00435-50, BT-AP00435-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines| oxidant-free radicals| ultraviolet irradiation| and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology; Immunology; Signal transduction; Epigenetics and nuclear signaling; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NFKB1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: NFKB\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P19838; Mouse: P25799; Rat: Q63369\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: NFKB; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor NF-kappa-B p50 subunit\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4790; Mouse: 18033\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238961012915,"sku":"BT-AP00435-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238961045683,"sku":"BT-AP00435-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238961078451,"sku":"BT-AP00435-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e5985b4a-ea96-4444-8086-d96dc1d91aa3.png?v=1769387297","url":"https:\/\/afsbio.com\/products\/nf-%ce%bab-p105-phospho-ser933-rabbit-polyclonal-antibody-bt-ap00435","provider":"AFSBio Inc.","version":"1.0","type":"link"}