{"product_id":"nf-κb2-p100-phospho-ser866-870-rabbit-polyclonal-antibody-es14500","title":"NF-κB2 p100 (phospho-Ser866\/870) Rabbit Polyclonal Antibody - ES14500","description":"\u003cp\u003eNF-κB2 p100 (phospho-Ser866\/870) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES14500-50, ES14500-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: nuclear factor kappa B subunit 2(NFKB2) Homo sapiens This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized phosho peptide around human NF-κB2 p100 (Ser866 and 870)\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: NF-κB p100\/p52\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of Human Mouse NF-κB2 p100 (phospho-Ser866 or 870)\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Leukemia, Lymph, Thymus,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 100kD\u003c\/p\u003e\n\n\u003cp\u003eFields: MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Legionellosis, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Viral carcinogenesis, Breast cancer\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma (B-NHL). Translocation t(10, 14)(q24, q32) with IGHA1. The resulting oncogene is also called Lyt-10C alpha variant\u003cbr\u003e\nDisease: A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL) cell line. This rearrangement produces the p80HT gene which encodes for a truncated 80 kDa protein (p80HT)\u003cbr\u003e\nDisease: In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous chromosomal aberrations, such as internal deletions\u003cbr\u003e\nDomain: The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and\/or transcription activation\u003cbr\u003e\nDomain: The glycine-rich region (GRR) appears to be a critical element in the generation of p52\u003cbr\u003e\nFunction: NF-kappa-B is a pleiotropic transcription factor which is present in almost a\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: NFKB2 LYT10\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: NF-κB2 p100 (Ser866\/870)\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 18034\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9WTK5\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315176034483,"sku":"ES14500-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315176067251,"sku":"ES14500-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/nf-%ce%bab2-p100-phospho-ser866-870-rabbit-polyclonal-antibody-es14500","provider":"AFSBio Inc.","version":"1.0","type":"link"}