{"product_id":"nf-kappab-p105-monoclonal-antibody-mb66917","title":"NF-kappaB p105 Monoclonal Antibody - MB66917","description":"\u003cp\u003eNF-kappaB p105 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66917-50, MB66917-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Transcription factors of the nuclear factor κB (NF-κB)\/Rel family play a pivotal role in inflammatory and immune responses . There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1, and NF-κB2. Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regμlate transcription. In unstimμlated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins . NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regμlates gene expression . NIK and IKKα regμlate the phosphorylation and processing of NF-κB2 to produce p52, which translocates to the nucleus .Following IKK-mediated phosphorylation of p105 NF-κB at mμltiple sites on its carboxy-terminus, SCF\/β-TrCP mediated processing produces the 50 kDa active form p50 .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human NF-kappaB p105. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IHC (1\/50 - 1\/200), FC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003ePurification: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of NF-kappaB p105 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 50, 120 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Regμlation of Apoptosis, Death Receptor Signaling, Inhibition of Apoptosis, NF-kB Signaling, T Cell Receptor Signaling\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P19838\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946423836851,"sku":"MB66917-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946423869619,"sku":"MB66917-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/nf-kappab-p105-monoclonal-antibody-mb66917","provider":"AFSBio Inc.","version":"1.0","type":"link"}