{"product_id":"nf-kb-p65-monoclonal-antibody-bt-mca2942","title":"NF-kB p65 Monoclonal Antibody - BT-MCA2942","description":"\u003cp\u003eNF-kB p65 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2942-50, BT-MCA2942-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Transcription factors of the nuclear factor k B (NF-kB)\/Rel family is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. There are five family members in mammals: RelA (p65), c-Rel, RelB, NF-kB1 (p105\/p50) and NF-kB2 (p100\/p52). The most studied NF-kB complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF-kB with its inhibitor, IkB. In most cell types, the p50\/p65 heterodimer is located within the cytoplasm complexed to IkB. This complex prevents nuclear translocation and activity of NF-kB. In response to stimuli such as cytokines, LPS, and viral infections, IkB is phosphorylated at critical residues. This phosphorylation induces dissociation of the IkB\/NF-kB complex, allowing the free heterodimeric NF-kB to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the kB site within promoters and enhancers and functions as a transcriptional activator.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NF-kB p65\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6H7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: NF-kB p65\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human NF-κB p65 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 65kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q04206\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: NFkappaB p65, p65, NFKB3, RELA\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5970\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238631039155,"sku":"BT-MCA2942-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238631071923,"sku":"BT-MCA2942-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_76984326-334e-4847-b6c0-cb7f7ca3e9c7.png?v=1769383234","url":"https:\/\/afsbio.com\/products\/nf-kb-p65-monoclonal-antibody-bt-mca2942","provider":"AFSBio Inc.","version":"1.0","type":"link"}