{"product_id":"nfatc4-phospho-ser168-s170-rabbit-pab-es6370","title":"NFATc4 (phospho Ser168\/S170) rabbit pAb - ES6370","description":"\u003cp\u003eNFATc4 (phospho Ser168\/S170) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6370-50, ES6370-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: NFATC4; NFAT3; Nuclear factor of activated T-cells; cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human NFAT3 around the phosphorylation site of Ser168 and Ser170. AA range:136-185\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 140kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 4776\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q14934\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm, cytosol. Nucleus. When hyperphosphorylated, localizes in the cytosol. When intracellular Ca (2+) levels increase, dephosphorylation by calcineurin\/PPP3CA leads to translocation into the nucleus (PubMed:11997522, PubMed:18347059). MAPK7\/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (PubMed:18347059).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202294309043,"sku":"ES6370-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202294341811,"sku":"ES6370-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_81b0079c-02df-4762-baa9-3b776b528f5f.png?v=1767125952","url":"https:\/\/afsbio.com\/products\/nfatc4-phospho-ser168-s170-rabbit-pab-es6370","provider":"AFSBio Inc.","version":"1.0","type":"link"}