{"product_id":"nfkb-p100-p52-polyclonal-antibody-e-ab-65807","title":"NFkB p100 \/ p52 Polyclonal Antibody - E-AB-65807","description":"\u003cp\u003eNFkB p100 \/ p52 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-65807-60, E-AB-65807-120, E-AB-65807-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: NFkB p100 \/ p52\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100; p49\/p100; p52\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q00653\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human NFkB p100 \/ p52 (NP_002493.3).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IF \t1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 47kDa\/96kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 125kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146389127347,"sku":"E-AB-65807-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146389160115,"sku":"E-AB-65807-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146389192883,"sku":"E-AB-65807-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_2a44a6f1-b987-4a75-9082-85d3c3791bcf.png?v=1710294706","url":"https:\/\/afsbio.com\/products\/nfkb-p100-p52-polyclonal-antibody-e-ab-65807","provider":"AFSBio Inc.","version":"1.0","type":"link"}