{"product_id":"nfkb1-monoclonal-antibody-bt-mca2641","title":"NFKB1 Monoclonal Antibody - BT-MCA2641","description":"\u003cp\u003eNFKB1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2641-50, BT-MCA2641-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NFKB1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5D10\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2a\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: NFKB1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human NFKB1 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 50kDa|105kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P19838\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: p50, KBF1, p105, EBP-1, MGC54151, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4790\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238599024819,"sku":"BT-MCA2641-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238599057587,"sku":"BT-MCA2641-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_879d9724-b531-4d43-ac98-d4eafdc4b395.png?v=1769382937","url":"https:\/\/afsbio.com\/products\/nfkb1-monoclonal-antibody-bt-mca2641","provider":"AFSBio Inc.","version":"1.0","type":"link"}