{"product_id":"nibrin-phospho-ser343-rabbit-pab-es6334","title":"Nibrin (phospho Ser343) rabbit pAb - ES6334","description":"\u003cp\u003eNibrin (phospho Ser343) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6334-50, ES6334-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11\/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: NBN; NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human p95\/NBS1 around the phosphorylation site of Ser343. AA range:310-359\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 95kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 4683\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: O60934\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Nucleus, PML body. Chromosome, telomere. Chromosome. Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN\/NBS1 assembly at the sites of DNA damage (PubMed:26438602).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202292801715,"sku":"ES6334-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202292834483,"sku":"ES6334-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_e136d95f-d643-4e0e-a227-5e3b7e20b9cc.png?v=1767125912","url":"https:\/\/afsbio.com\/products\/nibrin-phospho-ser343-rabbit-pab-es6334","provider":"AFSBio Inc.","version":"1.0","type":"link"}