{"product_id":"nipp1-polyclonal-antibody-bs5825","title":"NIPP1 Polyclonal Antibody-BS5825","description":"\u003cp\u003eNIPP1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS5825-50, BS5825-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Nuclear inhibitor of protein phosphatase 1; NIPP-1; Protein phosphatase 1 regulatory inhibitor subunit 8; Activator of RNA decay; ARD-1; PPP1R8; ARD1\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q12972\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: NIPP1 (nuclear inhibitor of protein phosphatase 1) is a putative transcription regulator that may be involved in pre-mRNA splicing and cell proliferation. NIPP1 contains a nuclear signaling region named FHA (fork-head associated) domain. The FHA domain has been associated with protein kinases and transcription factors. The NIPP1 locus encodes for three different isoforms termed α, β and γ due to alternative splicing events. The isoforms exhibit RNA binding activity and also act as phophatase inhibitors. The γ isoform is believed to be a magnesium dependent endoribonuclease that is responsible for cleaving RNA strands. It is mainly found in B cells and T lymphocytes. The α and β isoforms are localized in the brain and kidney. Inactivation of NIPP1 is accomplished by the phosphorylation of Ser 199 or Ser 204. NIPP1 interacts with proteins CDc5L, SAP 155, MELK and EED.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: NIPP1 polyclonal antibody detects endogenous levels of NIPP1 protein.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 38 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of NIPP1 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: Hela cell lysate\u003cbr\u003e\nLane 2: sp2\/0 cell lysate\u003cbr\u003e\nLane 3: H9C2 cell lysate\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 237-282 of Human NIPP1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42911818875059,"sku":"BS5825-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42911818907827,"sku":"BS5825-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_5dd476ef-f372-4146-9d66-690e313340df.jpg?v=1703179971","url":"https:\/\/afsbio.com\/products\/nipp1-polyclonal-antibody-bs5825","provider":"AFSBio Inc.","version":"1.0","type":"link"}