{"product_id":"nm23-h2-rabbit-polyclonal-antibody-es6396","title":"NM23-H2 Rabbit Polyclonal Antibody - ES6396","description":"\u003cp\u003eNM23-H2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6396-50, ES6396-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: NME2, NM23B, Nucleoside diphosphate kinase B, NDK B, NDP kinase B, C-myc purine-binding transcription factor PUF, Histidine protein kinase NDKB, nm23-H2\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human NM23. AA range:91-140\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: NM23-H2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: NM23-H2 Polyclonal Antibody detects endogenous levels of NM23-H2 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: [Isoform 1]: Ubiquitously expressed,, [Isoform 3]: Ubiquitously expressed,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 23kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Purine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Biosynthesis of cofactors\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate\u003cbr\u003e\nCofactor: Magnesium\u003cbr\u003e\nDisease: This protein is found in reduced amount in tumor cells of high metastatic potential\u003cbr\u003e\nDisease: This protein is found in reduced amount in tumor cells of high metastatic potential. Somatic mutations of NME1 are found in neuroblastoma. Increased NME1 in neuroblastoma is correlated with features of the disease that are associated with aggressive tumors. May therefore have distinct if not opposite roles in different tumors\u003cbr\u003e\nEnzyme Regulation: Autophosphorylation at His-118 increases serine\/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits exonuclease activity\u003cbr\u003e\nFunction: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13\/LBC. Acts as a transcriptional activator of the\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm Cell projection, lamellipodium Cell projection, ruffle Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates, [Isoform 1]: Cytoplasm Cytoplasm, perinuclear region Nucleus, [Isoform 3]: Cytoplasm Cytoplasm, perinuclear region Nucleus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: NME2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Nucleoside diphosphate kinase B\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 18103\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q01768\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 83782\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P19804\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313603334323,"sku":"ES6396-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313603367091,"sku":"ES6396-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/nm23-h2-rabbit-polyclonal-antibody-es6396","provider":"AFSBio Inc.","version":"1.0","type":"link"}