{"product_id":"nmna3-rabbit-polyclonal-antibody-es14476","title":"NMNA3 Rabbit Polyclonal Antibody - ES14476","description":"\u003cp\u003eNMNA3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES14476-50, ES14476-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the nicotinamide\/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human NMNA3 AA range: 97-147\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: NMNA3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of NMNA3 at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in lung and spleen with lower levels in placenta and kidney,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 28kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Nicotinate and nicotinamide metabolism, Metabolic pathways, Biosynthesis of cofactors\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)\u003cbr\u003e\nCatalytic Activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+)\u003cbr\u003e\nCofactor: Divalent metal cations. Magnesium confers the highest activity\u003cbr\u003e\nEnzyme Regulation: Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD)\u003cbr\u003e\nFunction: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form, nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotina\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Mitochondrion\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: NMNAT3 FKSG76\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: NMNA3\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 74080\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q99JR6\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315174396083,"sku":"ES14476-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315174428851,"sku":"ES14476-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/nmna3-rabbit-polyclonal-antibody-es14476","provider":"AFSBio Inc.","version":"1.0","type":"link"}