{"product_id":"noc2l-i634-polyclonal-antibody-bs3150","title":"NOC2L (I634) Polyclonal Antibody-BS3150","description":"\u003cp\u003eNOC2L (I634) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3150-50, BS3150-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9Y3T9\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC:1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: GADD 153, a growth arrest and DNA damage-inducible gene, encodes a C\/EBP-related nuclear protein. This protein has also been designated C\/EBP-homologous protein (CHOP-10 or C\/EBP zeta). GADD 153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and metabolic perturbations. GADD 153 functions to block cells in G1 to S phase during cell cycle progression and acts by dimerizing with other C\/EBP proteins to direct GADD 153 dimers away from “classical” C\/EBP binding sites, recognizing instead unique “nonclassical” sites. Thus, GADD 153 acts as a negative modulator of C\/EBP-like proteins in certain terminally differentiated cells. GADD 153 belongs to the CBF\/MAK21 family, which also includes NOC2L, NOC3L and NOC4L. NOC2L is a 749 amino acid nuclear protein that may play a role in cell cycle regulation.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemistry (IHC) analyzes of NOC2L (I634) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 85 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: NOC2L (I634) polyclonal antibody detects endogenous levels of NOC2L protein\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Nucleolar complex protein 2 homolog; Protein NOC2 homolog; NOC2-like protein; Novel INHAT repressor; NOC2L; NIR\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 602-650 of Human NOC2L.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42940142551219,"sku":"BS3150-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42940142583987,"sku":"BS3150-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_ddbe8c60-e7b6-4e10-af23-f9789f8aaf29.jpg?v=1704631474","url":"https:\/\/afsbio.com\/products\/noc2l-i634-polyclonal-antibody-bs3150","provider":"AFSBio Inc.","version":"1.0","type":"link"}