{"product_id":"nog1-polyclonal-antibody-bt-ap11940","title":"NOG1 Polyclonal Antibody - BT-AP11940","description":"\u003cp\u003eNOG1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11940-20, BT-AP11940-50, BT-AP11940-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. andapos;Activeandapos; in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: GTPBP4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Nucleolar GTP-binding protein 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9BZE4; Mouse: Q99ME9; Rat: Q99P77\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Nucleolar GTP-binding protein 1;Chronic renal failure gene protein;GTP-binding protein NGB\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 23560\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239241932979,"sku":"BT-AP11940-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239241965747,"sku":"BT-AP11940-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239241998515,"sku":"BT-AP11940-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_b3d16b3a-0550-4255-bc2a-e3a9aae1bb4b.png?v=1769391083","url":"https:\/\/afsbio.com\/products\/nog1-polyclonal-antibody-bt-ap11940","provider":"AFSBio Inc.","version":"1.0","type":"link"}