{"product_id":"nprl2-rabbit-pab-es3816","title":"NPRL2 rabbit pAb - ES3816","description":"\u003cp\u003eNPRL2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES3816-50, ES3816-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs., similarity:Belongs to the NPR2 family., subunit:Interacts with PDPK1., tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: NPRL2; TUSC4; Nitrogen permease regulator 2-like protein; NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from the C-terminal region of human NPRL2.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 43kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 10641\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q8WTW4\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Lysosome membrane. Localization to lysosomes is amino acid-independent.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202157240499,"sku":"ES3816-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202157273267,"sku":"ES3816-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_693c655b-dda4-4b6a-a2f3-cdfaed63d55b.png?v=1767123234","url":"https:\/\/afsbio.com\/products\/nprl2-rabbit-pab-es3816","provider":"AFSBio Inc.","version":"1.0","type":"link"}