{"product_id":"npy-rabbit-pab-es6406","title":"NPY rabbit pAb - ES6406","description":"\u003cp\u003eNPY rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6406-50, ES6406-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: NPY; Pro-neuropeptide Y\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC-p 1:100-500，WB 1:500-2000, ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human NPY. AA range:45-94\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 4852\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P01303\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201920262323,"sku":"ES6406-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201920295091,"sku":"ES6406-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_a4ee61e0-392e-4892-a973-f3a03164275a.png?v=1767117999","url":"https:\/\/afsbio.com\/products\/npy-rabbit-pab-es6406","provider":"AFSBio Inc.","version":"1.0","type":"link"}