{"product_id":"nr1h2-polyclonal-antibody-bt-ap12006","title":"NR1H2 Polyclonal Antibody - BT-AP12006","description":"\u003cp\u003eNR1H2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12006-20, BT-AP12006-50, BT-AP12006-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cardiovascular; Epigenetics and nuclear signaling; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NR1H2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Oxysterols receptor LXR-beta\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P55055; Mouse: Q60644; Rat: Q62755\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Oxysterols receptor LXR-beta;Liver X receptor beta;Nuclear receptor NER;Nuclear receptor subfamily 1 group H member 2;Ubiquitously-expressed nuclear receptor\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 7376\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239245045939,"sku":"BT-AP12006-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239245078707,"sku":"BT-AP12006-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239245111475,"sku":"BT-AP12006-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_a573b07e-bf4e-427b-ada0-974479cdd26b.png?v=1769391130","url":"https:\/\/afsbio.com\/products\/nr1h2-polyclonal-antibody-bt-ap12006","provider":"AFSBio Inc.","version":"1.0","type":"link"}