{"product_id":"nr1h4-polyclonal-antibody-bs66216","title":"NR1H4 Polyclonal Antibody - BS66216","description":"\u003cp\u003eNR1H4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS66216-50, BS66216-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The farnesoid X receptor (FXR\/NR1H4) is a member of the nuclear hormone receptor superfamily and is a master regμlator of bile acid synthesis. FXR\/NR1H4 heterodimerizes with RXR-alpha upon activation by bile acids, which begins a regμlatory cascade involving SHP and LRH-1 to control lipid homeostasis. FXR\/NR1H4 has also been shown to be a critical regμlator of glucose homeostasis. In addition to directly regμlating genes, FXR\/NR1H4 also plays a post transcriptional role in bile acid metabolism by transcribing the RNA-binding protein ZFP36L1, which in turn downregμlates the key enzyme Cyp7a1. Mutations in human FXR\/NR1H4 have been shown to cause cholestasis and liver disease in neonatal patients. FXR\/NR1H4 can also control Lgr5+ intestinal stem cell proliferation and its upregμlation has been shown to inhibit colorectal cancer progression. Agonists against FXR\/NR1H4 are being evaluated for various liver diseases and diabetes.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\/ICC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4, BAR, FXR, HRR1, RIP14\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from human FXR\/Bile Acid Receptor NR1H4.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:100\u003cbr\u003e\nIF\/ICC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: NR1H4 polyclonal antibody detects endogenous levels of NR1H4 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 56KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q96RI1\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45938581962931,"sku":"BS66216-50","price":349.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45938581995699,"sku":"BS66216-100","price":582.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_7d54f7f7-895a-4faa-805b-93c7ca9b170c.jpg?v=1788296274","url":"https:\/\/afsbio.com\/products\/nr1h4-polyclonal-antibody-bs66216","provider":"AFSBio Inc.","version":"1.0","type":"link"}