{"product_id":"nr2c2-monoclonal-antibody-mb66995","title":"NR2C2 Monoclonal Antibody - MB66995","description":"\u003cp\u003eNR2C2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66995-50, MB66995-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P49116\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2 . TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs) . TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation . TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation . High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2 . Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis .\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of NR2C2 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of NR2C2 expression in PC3 (A), Jurkat (B), MoLT4 (C), F9 (D), NIH3T3 (E), PC12 (F), CHO (G) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 67 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: TAK1; TR4; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide of human NR2C2. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42892001018035,"sku":"MB66995-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42892001050803,"sku":"MB66995-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_0a358a0d-2720-4ddb-bab3-2cff904721ee.jpg?v=1702468993","url":"https:\/\/afsbio.com\/products\/nr2c2-monoclonal-antibody-mb66995","provider":"AFSBio Inc.","version":"1.0","type":"link"}