{"product_id":"nrbp-rabbit-polyclonal-antibody-es10837","title":"NRBP Rabbit Polyclonal Antibody - ES10837","description":"\u003cp\u003eNRBP Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10837-50, ES10837-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: caution:Author states that kinase activity observed in PubMed:11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.,similarity:Belongs to the protein kinase superfamily. Ser\/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.,subunit:Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm.,tissue specificity:Ubiquitously expressed in all tissues examined with high levels in the testis.,\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: NRBP\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: NRBP Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitously expressed in all tissues examined with high levels in the testis,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 58kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Caution: Author states that kinase activity observed in PubMed: 11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive\u003cbr\u003e\nDomain: The protein kinase domain is predicted to be catalytically inactive\u003cbr\u003e\nFunction: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. Ser\/Thr protein kinase family\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSubcellular Location: Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia\u003cbr\u003e\nSubunit: Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm, cell cortex Endomembrane system Cell projection, lamellipodium Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: NRBP1 BCON3 NRBP\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Nuclear receptor-binding protein\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q99J45\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314335994035,"sku":"ES10837-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314336026803,"sku":"ES10837-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/nrbp-rabbit-polyclonal-antibody-es10837","provider":"AFSBio Inc.","version":"1.0","type":"link"}