{"product_id":"nsd1-polyclonal-antibody-bs71397","title":"NSD1 Polyclonal Antibody-BS71397","description":"\u003cp\u003eNSD1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS71397-50, BS71397-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q96L73\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB 1:500 - 1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: The nuclear receptor-binding SET domain-containing protein 1 (NSD1) belongs to a family of proteins which have all been implicated in human malignancy. The protein family includes NSD2 and NSD3, both of which show 70-75% sequence identity with NSD1 but contribute substantially less to overgrowth phenotypes. Defects and microdeletions of the NSD1 gene are involved in Sotos syndrome, childhood acute myeloid leukemia (AML), Weaver syndrome and Beckwith-Wiedemann Syndrome (BWS). The protein functions as a transcriptional intermediary factor capable of influencing transcription, either negatively or positively, depending on the cellular context. NSD1 is a nuclear protein expressed in brain, muscle, spleen, thymus, kidney and, to a lesser extent, lung.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: NSD1 polyclonal antibody detects endogenous levels of NSD1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 297 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot analysis of extracts of various cells, using NSD1 antibody.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: ARA267; KMT3B; H3-K36-HMTase; H4-K20-HMTase; Lysine N-methyltransferase 3B\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human NSD1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923497717939,"sku":"BS71397-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923497750707,"sku":"BS71397-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_124692bf-18d2-4766-acff-643217c09f00.jpg?v=1703850494","url":"https:\/\/afsbio.com\/products\/nsd1-polyclonal-antibody-bs71397","provider":"AFSBio Inc.","version":"1.0","type":"link"}