{"product_id":"nse2-polyclonal-antibody-bt-ap12036","title":"NSE2 Polyclonal Antibody - BT-AP12036","description":"\u003cp\u003eNSE2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12036-20, BT-AP12036-50, BT-AP12036-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated, possibly via autosumoylation.,Belongs to the NSE2 family.,Contains 1 SP-RING-type zinc finger.,subunit:Component of the SMC5-SMC6 complex which consists of SMC5, SMC6, NSMCE2\/MMS21 and probably NSMCE1.,\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology; Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NSMCE2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: E3 SUMO-protein ligase NSE2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q96MF7; Mouse: Q91VT1; Rat: Q4V8A0\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: E3 SUMO-protein ligase NSE2;EC 6.3.2.-;MMS21 homolog;hMMS21;Non-structural maintenance of chromosomes element 2 homolog;Non-SMC element 2 homolog\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 286053\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239249240243,"sku":"BT-AP12036-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239249273011,"sku":"BT-AP12036-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239249305779,"sku":"BT-AP12036-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_02b4213b-5691-4ba4-95de-4745c1d36386.png?v=1769392010","url":"https:\/\/afsbio.com\/products\/nse2-polyclonal-antibody-bt-ap12036","provider":"AFSBio Inc.","version":"1.0","type":"link"}