{"product_id":"nuclear-receptor-nr4a1-phospho-ser351-rabbit-polyclonal-antibody-es14439","title":"Nuclear Receptor NR4A1 (Phospho-Ser351) Rabbit Polyclonal Antibody - ES14439","description":"\u003cp\u003eNuclear Receptor NR4A1 (Phospho-Ser351) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES14439-50, ES14439-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1, Nuclear hormone receptor NUR\/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351)\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Nur77\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous pospho levels of human Nuclear Receptor NR4A1 (Phospho-Ser351)\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, ELISA(peptide)1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Fetal muscle and adult liver, brain and thyroid,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 77kD\u003c\/p\u003e\n\n\u003cp\u003eFields: MAPK signaling pathway, PI3K-Akt signaling pathway, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Orphan nuclear receptor\u003cbr\u003e\nInduction: By growth-stimulating agents\u003cbr\u003e\nSimilarity: Belongs to the nuclear hormone receptor family\u003cbr\u003e\nSimilarity: Belongs to the nuclear hormone receptor family. NR4 subfamily\u003cbr\u003e\nSimilarity: Contains 1 nuclear receptor DNA-binding domain\u003cbr\u003e\nSubunit: Interacts with GADD45GIP1\u003cbr\u003e\nTissue Specificity: Fetal muscle and adult liver, brain and thyroid\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Nucleus Cytoplasm Mitochondrion Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340) Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: NR4A1 GFRP1 HMR NAK1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Nuclear Receptor NR4A1 (Phospho-Ser351)\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315167514803,"sku":"ES14439-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315167547571,"sku":"ES14439-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/nuclear-receptor-nr4a1-phospho-ser351-rabbit-polyclonal-antibody-es14439","provider":"AFSBio Inc.","version":"1.0","type":"link"}