{"product_id":"nudt15-polyclonal-antibody-e-ab-62476","title":"NUDT15 Polyclonal Antibody - E-AB-62476","description":"\u003cp\u003eNUDT15 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62476-60, E-AB-62476-120, E-AB-62476-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: NUDT15\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: NUDT15; MTH2; NUDT15D\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9NV35\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human NUDT15 (NP_060753.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 18kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 19kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146246095027,"sku":"E-AB-62476-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146246127795,"sku":"E-AB-62476-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146246160563,"sku":"E-AB-62476-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d2ad56b0-3e72-48c1-a6d4-05364ecb3e87.png?v=1710292316","url":"https:\/\/afsbio.com\/products\/nudt15-polyclonal-antibody-e-ab-62476","provider":"AFSBio Inc.","version":"1.0","type":"link"}