{"product_id":"numb-rabbit-polyclonal-antibody-es4050","title":"NUMB Rabbit Polyclonal Antibody - ES4050","description":"\u003cp\u003eNUMB Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4050-50, ES4050-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: NUMB; Protein numb homolog; h-Numb; Protein S171\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from the Internal region of human NUMB.\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: NUMB,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: NUMB Polyclonal Antibody detects endogenous levels of NUMB protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IF\/ICC 1:100-500;ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: B cells, Blood, Brain, Cervix carcinoma, Epithelium, Fetal brain, HeLa cells, Live\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 70kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Notch signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Implicated in the control of cell fate decisions during development. PTM: Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. sequence Caution: Intron retention. Similarity: Contains 1 PID domain. Subunit: Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Cell membrane, Peripheral membrane protein, Cytoplasmic side Endosome membrane, Peripheral membrane protein, Cytoplasmic side Localizes to perinuclear endosomes in an AAK1-dependent manner.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: NUMB\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Protein numb homolog\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 8650\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: P49757\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 18222\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9QZS3\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q2LC84\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825500512435,"sku":"ES4050-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825500545203,"sku":"ES4050-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/numb-rabbit-polyclonal-antibody-es4050","provider":"AFSBio Inc.","version":"1.0","type":"link"}