{"product_id":"oas1-polyclonal-antibody-bs7726","title":"OAS1 Polyclonal Antibody-BS7726","description":"\u003cp\u003eOAS1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7726-50, BS7726-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P00973\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB\t1:500 - 1:2000\u003cbr\u003e\nIF\t1:50 - 1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: OAS1 polyclonal antibody detects endogenous levels of OAS1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 40 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot analysis of extracts of mouse liver cells, using OAS1 antibody.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: (2 5')oligo(A) synthetase 1; \u003cbr\u003e\n(2-5'')oligo(A) synthase 1; \u003cbr\u003e\n2 5 Oligoadenylate Synthetase 1; \u003cbr\u003e\n2 5' oligo A synthase 1; \u003cbr\u003e\n2 5' oligo A synthetase 1; \u003cbr\u003e\n2 5A synthase 1; \u003cbr\u003e\n2 5A synthetase 1; \u003cbr\u003e\n2' 5' oligo A synthetase 1; \u003cbr\u003e\n2' 5' oligoadenylate synthetase 1 40\/46kDa; \u003cbr\u003e\n2' 5' oligoadenylate synthetase 1; \u003cbr\u003e\n2' 5' oligoisoadenylate synthetase 1; \u003cbr\u003e\n2''-5''-oligoadenylate synthase 1; \u003cbr\u003e\n2'5' oligo A synthetase 1; \u003cbr\u003e\n2'5' oligoadenylate synthetase 1; \u003cbr\u003e\n2'5' oligoisoadenylate synthetase 1; \u003cbr\u003e\n2-5A synthase 1; \u003cbr\u003e\nE18\/E16; \u003cbr\u003e\nIFI 4; \u003cbr\u003e\nIFI4; \u003cbr\u003e\nOAS 1; \u003cbr\u003e\nOAS1; \u003cbr\u003e\nOAS1_HUMAN; \u003cbr\u003e\nOIAS; \u003cbr\u003e\nOIASI; \u003cbr\u003e\np46\/p42 OAS;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant full length Human OAS1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923472388275,"sku":"BS7726-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923472421043,"sku":"BS7726-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_64c3ba50-45e7-41fd-a7c3-2f6802e9f5df.jpg?v=1703850113","url":"https:\/\/afsbio.com\/products\/oas1-polyclonal-antibody-bs7726","provider":"AFSBio Inc.","version":"1.0","type":"link"}