{"product_id":"oct-4-monoclonal-antibody-bt-mca4034","title":"OCT-4 Monoclonal Antibody - BT-MCA4034","description":"\u003cp\u003eOCT-4 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4034-50, BT-MCA4034-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Oct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3\/4, also known as POU5F1(POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Entrez Protein NP_002692. Oct-3\/4 sustains stem-cell selfrenewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3\/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3\/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3\/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: OCT-4\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1D10H6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: OCT-4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of Oct4 (aa193-360) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 38.5kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q01860\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: OCT3, OTF3, OTF4, MGC22487, POU5F1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5460\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238428172467,"sku":"BT-MCA4034-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238428205235,"sku":"BT-MCA4034-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_9827e1ea-8ffb-447c-bbd0-a847fe1e97a8.png?v=1769380650","url":"https:\/\/afsbio.com\/products\/oct-4-monoclonal-antibody-bt-mca4034","provider":"AFSBio Inc.","version":"1.0","type":"link"}