{"product_id":"p130-cas-rabbit-polyclonal-antibody-es3094","title":"p130 Cas Rabbit Polyclonal Antibody - ES3094","description":"\u003cp\u003ep130 Cas Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES3094-50, ES3094-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: BCAR1, CAS, CASS1, CRKAS, Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human p130 Cas. AA range:376-425\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: p130 Cas\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p130 Cas Polyclonal Antibody detects endogenous levels of p130 Cas protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed with an abundant expression in the testis, Low level of expression seen in the liver, thymus, and peripheral blood leukocytes, The protein has been detected in a B-cell line,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 130kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Rap1 signaling pathway, Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Growth hormone synthesis, secretion and action, Bacterial invasion of epithelial cells, Shigellosis, Yersinia infection, Human cytomegalovirus infection\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: A serine-rich region promotes activation of the serum response element (SRE)\u003cbr\u003e\nDomain: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL\u003cbr\u003e\nDomain: The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1\u003cbr\u003e\nFunction: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells\u003cbr\u003e\nPTM: Focal adhesion kinase 1 phosphoryl\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell junction, focal adhesion Cytoplasm Cell projection, axon Unphosphorylated form localizes in the cytoplasm (By similarity) Localizes to focal adhesion sites following integrin engagement (By similarity)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: BCAR1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Breast cancer anti-estrogen resistance protein 1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 12927\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q61140\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 25414\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q63767\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46316466733235,"sku":"ES3094-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46316466766003,"sku":"ES3094-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/p130-cas-rabbit-polyclonal-antibody-es3094","provider":"AFSBio Inc.","version":"1.0","type":"link"}