{"product_id":"p16-ink4a-polyclonal-antibody-bs66210","title":"p16 INK4a Polyclonal Antibody - BS66210","description":"\u003cp\u003ep16 INK4a Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS66210-50, BS66210-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The progression of cells through the cell cycle is regμlated by a family of proteins designated cyclin-dependent kinases (Cdks). Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Mμltiple proteins are encoded by the tumor suppressor gene CDKN2A (MTS1\/ p16INK4a) via translation of alternate reading frames, resμlting in the production of the p19 ARF protein in mice and the p14 ARF protein in humans. p14 ARF induces an increase in MDM2 and p21 levels and leads to cell cycle arrest in both G1 and G2\/M. p14 ARF is negatively regμlated by p53 and is known to bind directly to MDM2. CDKN2A also encodes the mitotic protein p16, which binds to and inhibits the Cdk4\/cyclin D complex.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\/ICC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CDKN2, MTS1, Cyclin-dependent kinase inhibitor 2A isoforms 1\/2\/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Mμltiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide of human p16 INK4a.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:2000\u003cbr\u003e\nIHC: 1:50~1:200\u003cbr\u003e\nIF\/ICC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p16 INK4a Polyclonal Antibody detects endogenous levels of p16 INK4a protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 17 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P42771\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45938581668019,"sku":"BS66210-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45938581700787,"sku":"BS66210-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_7d54f7f7-895a-4faa-805b-93c7ca9b170c.jpg?v=1788296274","url":"https:\/\/afsbio.com\/products\/p16-ink4a-polyclonal-antibody-bs66210","provider":"AFSBio Inc.","version":"1.0","type":"link"}